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Dynamic Light Scattering (DLS), Dynamic Light Scattering (DLS), Microtrac Particle Characterization, Particle Size & Shape Analysis, Stability & Dispersibility Analysis

Microtrac NANOTRAC WAVE II DLS Size and Zeta Potential Analyzer

Nanoparticle size, zeta potential, molecular weight and concentration in one benchtop DLS instrument — 0.3 nm to 10 µm, ±200 mV, up to 40 % concentration.

  • 180° backscatter with Laser Amplified Detection — no fitting model to choose
  • pH titration for zeta vs. pH · FDA 21 CFR Part 11 compliant
  • Installation and on-site training included · free test measurement
  • Configured to order · lead time from 4 weeks

Request a formal quotation →

Prices follow supplier cost and stock availability and are updated regularly. The price you see is today's price — once you order, it's held for 7 days.
Installation + training included Free test measurement
0.3 nm–10 µm size range
±200 mV zeta range
ISO 22412 conformant
21 CFR 11 data integrity
Built for nanoparticle R&D teams

What your nano lab actually checks

Size, zeta and MW in one

Particle size, zeta potential (±200 mV), molecular weight and concentration on the same stable 180° backscatter optics — with automated titration for isoelectric point and temperature control. No second instrument, and calculations conform to ISO 22412 and 21 CFR Part 11.

An applications engineer on the line

0.3 nm–10 µm
Size range
±200 mV
Zeta range
up to 40%
Concentration
20×10⁶ Da
Max mol. weight
ISO 22412
Standard
About this product
Price

Quoted to your configuration
The price depends on the sample cells your materials need — Teflon or stainless steel, in several volumes — and on the zeta potential and titration setup. You receive a formal quotation on our letterhead with configuration, price, payment terms and lead time: the document your purchasing department asks for. Installation and on-site operator training are included in every quotation. Lead time from 4 weeks, depending on the configuration; the quotation gives the date.
What you configure

  • NANOTRAC WAVE II base unit — fixed 180° backscatter probe, 780 nm laser, two laser diodes for zeta potential
  • Removable, reusable sample cells in Teflon or stainless steel
  • Removable zeta potential sample cell, 150 µL – 2 mL, easy to take out for cleaning
  • pH titration for zeta potential versus pH
  • DIMENSIONS LS software; FDA 21 CFR Part 11 compliant operation
  • Installation and on-site operator training — included in every quotation
Next stepRequest a formal quotation

The test measurement of your sample is free: you get the size and zeta report and we go through it with you before you decide.
0.3 nm – 10 µmSize range by 180° backscatter DLS
−200 to +200 mVZeta potential, particles 10 nm – 20 µm
Up to 40 %Sample concentration, sample dependent
<300 Da – 20×106 DaMolecular weight; concentration also reported

What the NANOTRAC WAVE II is

The NANOTRAC WAVE II is a benchtop dynamic light scattering analyzer from Microtrac that measures nanoparticle size, zeta potential, molecular weight and concentration with one fixed optical probe. Laser light at 780 nm passes through a sapphire window into the sample; part of it is reflected back at the window and mixes with the light the particles scatter at 180°. This Laser Amplified Detection gives up to 106 times the signal-to-noise ratio of photon correlation spectroscopy, and a frequency power spectrum calculation returns narrow, broad and multimodal distributions without any prior information about the sample. Zeta potential is measured on the same optics: an electric field is applied, and the instrument reads particle mobility and polarity from the change in the power spectrum.

Specifications

Method backscattered laser-amplified scattering reference method
Calculation model FFT power spectrum
Measurement angle 180°
Size range 0.3 nm – 10 µm
Zeta potential range −200 to +200 mV
Zeta size range 10 nm – 20 µm
Electrophoretic mobility 0 – 15 (µm/s)/(V/cm)
Conductivity range 0 – 10 mS/cm
Molecular weight range <300 Da to 20 × 106 Da
Temperature control +4 to +90 °C, ±0.1 °C
Titration pH · endpoints pH, volume
Reproducibility size ≤ 1 % · zeta ±3 %
Sample volume size 50 µL – 3 mL · zeta 150 µL – 2 mL
Sample concentration up to 40 % (sample dependent)
Carrier fluids water, polar and non-polar organic solvents, acid and base
Laser 780 nm, 3 mW; 2 laser diodes with zeta
Humidity 90 % non-condensing
Dimensions (W × H × D) 355 × 381 × 330 mm (14.0 × 15.0 × 13.0 in)
Standards ISO 13099-2:2012, ISO 22412:2017 · FDA 21 CFR Part 11 compliant
Installation and training on site, included in every quotation
Lead time from 4 weeks, depending on configuration

Download: NANOTRAC WAVE II datasheet (PDF) · NANOTRAC series brochure (PDF) · Molecular weight application note (PDF) · Inkjet ink application note (PDF)

What it tells you about a nanoparticle dispersion

Size alone does not say whether a dispersion will stay dispersed. These are the numbers that do:

Size distribution narrow, broad or multimodal, with no model to choose; results in as little as 30 seconds
Zeta potential the electrostatic repulsion between particles — positive or negative, and how strong
Zeta versus pH where the charge goes to zero and in which pH range the dispersion stays charged
Molecular weight by hydrodynamic radius or Debye plot; the second virial coefficient shows whether molecules tend to aggregate
Concentration from the loading index, in cm³/mL or particles per mL

Microtrac application notes show inks of all colors measured at high concentration, where a bimodal distribution stands out clearly, and molecular weights of dextran and polyethylene oxide determined by Debye plot on a NANOTRAC instrument.

The probe also takes concentrated samples up to 40 %, sample dependent, so in many cases the dispersion is measured close to its real state instead of after heavy dilution.

Three measurements on the same optics

Particle size0.3 nm to 10 µm by 180° backscatter DLS. The frequency power spectrum handles mono- and multimodal samples without asking the operator to choose cumulants, NNLS or CONTIN.
Zeta potential±200 mV for particles from 10 nm to 20 µm. Two coated probes measure polarity in a pulsed field and mobility in a high-frequency field; rapid field reversal prevents electro-osmosis, also at high concentration.
Molecular weight and concentrationMolecular weight from below 300 Da to 20 × 106 Da, by hydrodynamic radius or Debye plot. Concentration from the loading index of the power spectrum.

Where the NANOTRAC WAVE II stops — and what to take instead

The NANOTRAC WAVE II stops at 10 µm for size and at 10 nm – 20 µm for zeta potential. Its conductivity range is 0 – 10 mS/cm and its titration is pH only. For dispersions with high salt content, polyelectrolyte or salt titrations, or charge on particles up to 300 µm, the STABINO ZETA measures streaming potential with conductivity up to 350 mS/cm. If you need to measure inside a reaction vessel or a pipe, the dip-probe NANOTRAC FLEX does that. Above 10 µm, laser diffraction is the method: see the BLUEWAVE or the SYNC.

In pictures

Microtrac NANOTRAC WAVE II DLS nanoparticle size and zeta potential analyzer
The benchtop NANOTRAC WAVE II — size, zeta potential, molecular weight and concentration in one instrument.
Pharmaceutical nanoparticles and LNPs sized on the NANOTRAC WAVE II
Pharma & life sciences — LNP charge and protein stability.
Emulsions and colloids sized and charged on the NANOTRAC WAVE II
Colloids & emulsions — stability and isoelectric point.
Metal and ceramic nanomaterials characterized on the NANOTRAC WAVE II
Metal & ceramic nanomaterials — slip stability, zeta vs pH.

Availability, payment and delivery

Built to orderEach instrument is configured with the sample cells and zeta setup for your materials. Lead time is from 4 weeks after a confirmed order, depending on the configuration; the quotation states the date in writing.
How you payAsk for a formal quotation on our letterhead and pay against an invoice. We are registered in SAM.gov as a small business, so federal and university purchasing works the usual way.
What arrivesThe NANOTRAC WAVE II with the sample cells and zeta cell you ordered and DIMENSIONS LS software. Installation and on-site operator training are included in every quotation and carried out by Microtrac’s US service engineers.

Why buy it through Additive Plus

Authorized Microtrac resellerQuotation, order and delivery handled by one team in California
Installation and training includedSet up on site and your team trained on size, zeta potential, titration and molecular weight — part of every quotation
Free test measurementSend a sample of your dispersion and decide with the size and zeta report in hand

What usually stops people — and the honest answer

“We would need two instruments for size and zeta.”The NANOTRAC WAVE II measures size, zeta potential, molecular weight and concentration on the same optics, with no adjustment between them.
“Our samples are too concentrated for DLS.”The probe measures backscatter at 180° right at the sapphire window, and Laser Amplified Detection keeps the signal strong: concentrations up to 40 % are possible, depending on the sample.
“We are a regulated lab.”The NANOTRAC series is FDA 21 CFR Part 11 compliant and follows ISO 22412:2017 for DLS and ISO 13099-2:2012 for zeta potential.
“Choosing a DLS fitting model is a matter of opinion.”Not here. The frequency power spectrum calculation needs no a priori information and no choice between cumulants, NNLS or CONTIN — one calculation for all sample types.

Ready when you are

Brand Microtrac
Country of origin USA
Measurement principle Backscattered laser-amplified scattering reference method
Measuring range 0.3 nm - 10 µm
Calculation Model FFT power spectrum
Measurement angle 180°
Sample cell Various sample cell options
Zeta potential analysis yes
Zeta measurement range (potential) -200 mV - +200 mV
Zeta measurement range (size) 10 nm - 20 µm
Electrophoretic mobility 0 - 15 (µm/s) / (V/cm)
Conductivity measurement yes
Conductivity range 0 - 10 mS / cm
Molecular weight measurement yes
Molecular weight range <300 Da -> 20 x 10^6 Da
Temperature range +4°C - +90°C
Temperature accuracy ± 0.1°C
Temperature control yes
Temperature control range +4°C - +90°C
Titration yes
Reproducibility (size) =< 1%
Reproducibility (zeta) + / - 3%
Sample volume size measurement 50 µl - 3 ml
Sample volume zeta measurement 150 µl - 2 ml
Concentration measurement yes
Sample concentration up to 40 % (sample dependent)
Carrier fluids Water, polar and unpolar organic solvents, acid and base
Laser 780 nm, 3 mW; 2 laser diodes with zeta
Humidity 90 % non-condensing
Dimensions (W x H x D) 14.0×15.0×13.0 in / 355×381×330 mm

Product videos

Want to see it on your powder first?

We run this lab daily. Send a sample.

Send us a powder sample and we'll run PSD and morphology on the actual instrument, then share the data and method — so you see repeatability before you buy. We can also run analysis as a service while you evaluate.

What our customers say

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Common questions

Don't see yours? Email [email protected] — NDA standard, typical reply within 4 hours.

What does the NANOTRAC WAVE II measure?
The NANOTRAC WAVE II measures nanoparticle size (0.3 nm – 10 µm), zeta potential (−200 to +200 mV for particles of 10 nm – 20 µm), molecular weight (below 300 Da up to 20×10⁶ Da), concentration and conductivity in one benchtop DLS instrument. Size and charge come from the same fixed optics, with 180° backscatter and Laser Amplified Detection.
How does the WAVE II measure zeta potential?
Zeta potential uses the same power spectrum method as sizing. The probe surface in the zeta cell is coated to make electrical contact with the sample; one probe determines polarity in a pulsed electric field, the other measures mobility in a high-frequency sine-wave field. Rapid field reversal prevents electro-osmosis, and mobility is calculated from a ratio of power spectra, which keeps the measurement robust at high concentration.
Can it measure concentrated samples?
Yes, up to 40 % concentration, depending on the sample. Laser Amplified Detection and the 180° backscatter geometry at the probe window make that possible for both size and zeta potential, so a concentrated formulation does not have to be diluted heavily before measurement.
Does it support zeta-versus-pH titration?
Yes. The NANOTRAC WAVE II supports pH titration with pH and volume endpoints, so you can map zeta potential against pH and find where the charge goes to zero. Temperature is controlled from +4 to +90 °C with ±0.1 °C accuracy. For polyelectrolyte or salt titrations, the STABINO ZETA is the instrument.
Is the NANOTRAC WAVE II suitable for regulated pharmaceutical work?
Microtrac states that the NANOTRAC series is FDA 21 CFR Part 11 compliant and follows ISO 22412:2017 for dynamic light scattering and ISO 13099-2:2012 for zeta potential. Data protection according to 21 CFR Part 11 is shown on the result printout.
How is the WAVE II different from the NANOTRAC FLEX?
Both use the same NANOTRAC probe technology and size range. The WAVE II is a benchtop instrument with internal sample cells that adds zeta potential, conductivity and pH titration. The NANOTRAC FLEX has an external dip probe for any vessel, measures size, concentration and molecular weight, and can work at line or in line — but it does not measure zeta potential.
Can it measure liposomes for drug delivery?
Particle size of liposome capsules for drug delivery systems is one of Microtrac's application examples for the NANOTRAC series. Size control matters there because it decides how much of a drug is absorbed at a specific site. Send a sample and the free test measurement shows how your formulation behaves.
How much does a NANOTRAC WAVE II cost?
The price depends on the configuration — the sample cells, the zeta potential cell and the titration setup. Request a formal quotation and you receive configuration, price, payment terms and lead time on our letterhead. Installation and on-site operator training are included in every quotation.
Can I test my sample before buying?
Yes, and the test measurement is free. Send a representative sample; it is measured in Microtrac's US application lab and you receive the size and zeta report, which we go through with you before you decide.
What is the lead time, and what comes with the NANOTRAC WAVE II?
The NANOTRAC WAVE II is configured to order. Lead time is from 4 weeks after a confirmed order, depending on the configuration, and the formal quotation states the date. Installation and on-site operator training by Microtrac's US service engineers are included in every quotation.

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